COENZYME Q10

Coenzyme Q10 or “CoQ10”, also known as ubiquinone, is an anti-oxidant that is essential for mitochondrial energy production and may play a role in cellular defense against oxidative damage. A growing body of research shows that using a coenzyme Q10 supplement alone or in combination with other therapies may be beneficial in the treatment of several health problems, including cardiac conditions and diseases, high blood pressure, high cholesterol, breast cancer, diabetes mellitus, immune deficiency, muscular dystrophy, and periodontal disease.

Dietary Sources
Most coenzyme Q10 is believed to be synthesized inside the body. Normal dietary intake is minimal, though primary food sources include oily fish, organ meats (such as liver), nuts, and whole grains. Supplementation with higher doses of CoQ10 can be helpful in individuals with certain health conditions, and in the elderly, because levels can decline with advancing age. If taken as a supplement, coenzyme Q10 should be taken with a meal containing fat or oil since it is fat-soluble. The body does not absorb it as well in the absence of oil. Consult your physician for specific recommendations CoQ10 supplementation.

Precautions
Coenzyme Q10 appears to be safe with no significant side effects. However, the safety of supplementation during pregnancy and breast-feeding is unknown.

Possible Interactions
Certain medications such as Adriamycin, lovastatin and other HMG CoA-reductase inhibitors, gemfibrozil, beta-blockers, tricyclic antidepressants, and phenothiazine may deplete the body of coenzyme Q10.

Resources
1. Combs, G.F., The Vitamins: Fundamental Aspects in Nutrition and Health. 2nd ed. 1998, San Diego, Calif.: Academic Press. xxii, 618.
2. Gaby, A.R. and J. Wright, Nutritional Therapy in Medical Practice. 2001, Seattle, WA: Nutrition Seminars.
3. MD Consult, Patient Handouts. 2002, http://www.mdconsult.com.

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